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KMID : 0043320160390050713
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Archives of Pharmacal Research
2016 Volume.39 No. 5 p.713 ~ p.720
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Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum
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Lee Ji-Young
Kim Kwang-Jin
Kim Jin-Hee
Choi Sang-Un
Kim Seong-Hwan
Ryu Shi-Yong
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Abstract
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A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related isoquinoline alkaloids (1?13) including two new compounds, 1 and 2. Among isolated compounds, salutaridine (7), dauricumine (10), cheilanthifoline (12), and dauriporphine (13) were observed to give significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts, respectively. The chemical structures of two newly isolated compounds, 1 and 2 were established as 8-demethoxycephatonine (1) and 7(R)-7,8-dihydrosinomenine (2), by spectroscopic analyses including 2D NMR experiments.
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KEYWORD
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Sinomenium acutum, Menispermaceae, Isoquinoline alkaloids, Anti-osteoclastogenic effect
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